Feeding infected fish with antibiotic-medicated food and the application of antibiotics via the oral route is the common practices used to control vibriosis (Defoirdt et al., 2007; Pridgeon and Klesius, 2012). However, its value is limited since clinically affected fish do not eat and therefore cannot be treated. Some Main antimicrobial agents used in aquaculture are Amoxicillin, Ampicillin, Chloramphenicol, Florfenicol, Erythromycin, Streptomycin, Neomycin, Furazolidone, Nitrofurantoin, Oxolinic acid, Enrofloxacin, Flumequine, Oxytetracycline, Tetracycline and Sulphanomides (Defoirdt et al., 2007; Heuer et al., 2009). Many antimicrobial agents used in aquaculture are used in human medicine and are classified by the World health organization as critically important for use in humans. Development of resistance to antimicrobial compounds in pathogen, residual antibiotics in aquaculture products and environments are the issues identified due to the frequent use of antimicrobial compounds. (Defoirdt et al., 2007; Novriadi, 2016).