As apsychiatrist, one would be keen to either control or eliminate emotionaldifficulties of patients through therapeutic interventions that have minimalside-effects. Identification of key neurobiological targets those are amenableto interventions would form a very first step towards such treatments.
However,numerous abnormalities in the brain circuitry that emotional setback embraces,besides identification and deciphering specific circuits involved in thealteration of neurocircuitry of complex process also presents a greatchallenge. The problem just does not gets solved here, but stretches itself toidentification of potential biological characteristics be it either non codingRNA(s) or genes specifically expressed in a particular circuit. Further,examination of putative alteration/expression of biological marker with respectto other molecules in a single cohort would help to extract more comprehensiveunderstanding of neurocircuits that underlie complex process like emotion,thinking and learning.
Therefore, identification and understanding of biologicalcharacteristics more or less related to a particular circuit that forms keypoint in a complex process is the area that more often interests me.Past couple ofdecade has seen technology being subjected to groundbreaking advancement whichprovides a tool to scientific community to study molecular mechanism of complexprocess more efficiently and accurately. Meanwhile, collaborative effortsacross several domains have yielded valuable synergy towards deciphering empiricaldata and providing significant/useful information for further investigations.Computational approaches offers great deal to approximate biological activity andconclude several rules that might be involved in controlling the complexprocess.
At the same time, integration of systems biology approaches with thatof network biology and statistics has proven to provide a better overview ofinteractions/activity that a biological characteristic is involved in withother molecules.Hence, I wouldlike to investigate potential relationships/interactions that might existbetween non coding RNA(s) and stimulant based epigenetic pattern with that ofanatomical projections and its effect as a whole on neurocircuitry of emotionsthrough an approach that integrates concepts from systems neuroscience.Conclusively, identifying key waypoints that plays substantial role in theregulation/alteration of complex neuro-circuits of emotions and memory.