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nanoparticles              Figure4 Standard calibration curve of the 5-FU Solution in between Concentration (µg/ml) vsAbsorbance (nm).Abbreviations: 5-FU, 5-Fluorouracil.              pH 7.

4   pH 4.5   Figure 5 In vitroreleases of ?-T-FU-PLGA-NPs and 5-FU-PLGA-NPs in PBS at pH 7.4 & 4.5.Abbreviations:?-T-FU-PLGA-NPs, targeted ?-Tocopherol-5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; 5-FU-PLGA-NPs non-targeted 5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; PBS, phosphate buffer saline.          (A)(B)      Figure6 Cytotoxicity study, Inhibition rate of?-T-FU-PLGA-NPs and 5-FU-PLGA-NPs in SCC15 cells detected by MTT assay. (n=3;mean ± standard deviation).Notes: (A) Inhibition rate of differentdose-concentration-time (24, 48, 72 hours) of 5-FU-PLGA-NPs on SCC15 cells.

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(B) Inhibition rate of differentdose-concentration-time (24, 48, 72 hours) of ?-T-FU-PLGA-NPs on SCC15 cells.Abbreviations:?-T-FU-PLGA-NPs, targeted ?-Tocopherol-5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; 5-FU-PLGA-NPs, non-targeted 5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; SCC15, squamous cell carcinoma-15 cells; MTT, methyl thiazolyltetrazolium assay.                  Figure7 Cytotoxicity study, Inhibition rate of ?-T-FU-PLGA-NPs and5-FU-PLGA-NPs on SCC15 cells up to time 160 hours.Abbreviations:?-T-FU-PLGA-NPs, targeted ?-Tocopherol-5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; 5-FU-PLGA-NPs, non-targeted 5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; SCC15, squamous cell carcinoma-15 cells.              (A)(B)Figure8 Inhibition of ?-T-FU-PLGA-NPs and 5-FU-PLGA-NPs ondrug-resistant SCC15 cells detected by MTT assay.Notes:(A) Dose-concentration dependentinhibition rate (B) Time-dependent inhibition rate.Abbreviations:?-T-FU-PLGA-NPs, targeted ?-Tocopherol-5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; 5-FU-PLGA-NPs, non-targeted 5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; SCC15, squamous cell carcinoma-15 cells; MTT, methyl thiazolyltetrazolium assay. Figure9 Cell viability assays of ?-T-FU-PLGA-NPs and5-FU-PLGA-NPs in SCC-15 at the concentration of 1.

0mg/ml, .05mg/ml &0.1mg/ml.

Abbreviations:?-T-FU-PLGA-NPs, targeted ?-tocopherol-5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; 5-FU-PLGA-NPs, non-targeted 5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; SCC15, squamous cell carcinoma-15 cells.             Figure:10- Cellular Uptake of FITC labeled ?-T-FU-PLGA-NPs and 5-FU-PLGA-NPsNotes(A) ?-T-FU-PLGA-NPs(B) 5-FU-PLGA NPs in SCC15 byFluorescent Microscopy analysis on the scale bar is 50 ?mAbbreviations:?-T-FU-PLGA-NPs, targeted ?-tocopherol-5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; 5-FU-PLGA-NPs, non-targeted 5-Fluorouracil-poly(D,L-lactic-co-glycolic)nanoparticles; SCC15, squamous cell carcinoma-15 cells; FITC, FluoresceinIsothiocyanate.

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