The incorporation of H2A

The incorporation of H2A.Z directly to nucleosomes is conveyed through the SWR1 complex in plants that is made up of proteins encoded by ACTIN-RELATED PROTEIN 6 (ARP6), SWC6 and PHOTOPERIOD-INDEPENDENT EARLY FLOWERING1 (PIE1) (Tasset, Yadav et al. 2018). massive rearrangement of transcription-associated with cell distinction during development includes switch on and off of many genes (March-Diaz, Garcia-Dominguez et al. 2007). In plants, H2A.Z is associated to the response to turbulent temperature, the phosphate starvation response, osmotic pressure, the immune response, floral induction, female meiosis, recombination, thalianol metabolism, and the modulation of microRNA abundance (Qin, Zhao et al. 2014, Xu, Leichty et al. 2018). This task requires enormous rearrangement in chromatin assembly as it has been evidenced by the recognition of chromatin-remodeling factors whose mutation impairs regular development at multiple and different levels (March-Diaz, Garcia-Dominguez et al. 2007). Three most important biochemical methods or mechanisms have been described to alter chromatin configuration and assembly. The first requires the posttranslational covalent alteration of the amino- and carboxy-terminal ends of histones. The model of chemical alteration of histones within a nucleosome (acetylation, methylation, phosphorylation, ubiquitination, and SUMOylation) seems to constitute a code that can be interpreted by other nuclear machinery (March-Diaz, Garcia-Dominguez et al. 2007). Second is the ATP-dependent redirection of interactions between DNA and histones, which induce the deformation of the nucleosome assembly. The third medium of chromatin remodelling resides in the substitution of canonical histones of the octamer by histone variants, which confers balance to the nucleosome (Mizuguchi, Shen et al. 2004, Kamakaka and Biggins 2005, March-Diaz, Garcia-Dominguez et al. 2007).


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