The majority Ethiopian women are largely engaged in the agricultural sector, which is highly vulnerable to climate changes. This study, aims at analyzing the determinants of women’s response measures of climate change in the Dubti Woreda. This article designed as a cross-sectional research design and employed qualitative and quantitative research approaches. Data was obtained from primary and secondary sources. Moreover, both the probability and non probability sampling techniques were employed. Accordingly, this article found that five major response mechanism to the consequence of climate change. The result from the binary logistic model reveals that age, access to training, farming experience, access to credit service, radio and mobile services determines women’s response methods to the consequence of climate changes. Finally, the article recommends for greater investment in women education and training to address the above mentioned challenges.